The semi-natural cycle is an alternative method of in vitro fertilization (IVF) that bridges the gap between the natural and fully stimulated cycles. In this process, mild pharmaceutical stimulation is used to mature 1 to 3 follicles, largely following the natural rhythm of the woman’s body.

This method is preferred by women with low ovarian response, those who have difficulty using high doses of hormones, or simply those who desire a more natural and less burdensome process. The semi-natural cycle reduces the risk of ovarian hyperstimulation syndrome (OHSS), minimizes the side effects of medication, and maintains the quality of the eggs at high levels.

Although it may produce fewer eggs compared to the fully stimulated cycle, the quality of the eggs collected is often considered superior, which increases the chances of successful implantation and pregnancy.